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Paget's disease of bone disrupts the normal cycle of bone renewal, causing bones to become weakened and possibly deformed.
It's a fairly common condition in the UK, particularly in older people. It's rare in people under 50 years of age.
There are treatments that can help keep it under control for many years, but it can cause persistent pain and a range of other problems in some people.
This page covers:
Paget's disease of bone can affect one or several bones. Commonly affected areas include the pelvis, spine and skull.
Symptoms can include:
But in many cases there are no symptoms and the condition is only found during tests carried out for another reason.
Read more about the symptoms of Paget's disease of bone.
See your GP if you have:
Your GP can organise tests to check your bones and look for problems such as Paget's disease of bone.
Read more about how Paget's disease of bone is diagnosed.
Bone cells regenerate in a similar way to skin – old bone is removed and replaced by new bone. This is known as bone remodelling.
Two cells are responsible for this:
In Paget's disease of bone, something goes wrong with the osteoclast cells and they start to absorb bone at a much faster rate than usual.
The osteoblasts then try to produce new bone more quickly, but the new bone is larger and weaker than normal.
It's not clear what triggers this, but you're at a higher risk if you have a family history of Paget's disease of bone. You may inherit a genetic fault that means you're much more likely to develop the condition.
There's currently no cure for Paget's disease of bone, but treatment can help relieve the symptoms.
If you don't have any symptoms, your doctor may suggest keeping an eye on your condition and delaying treatment until any problems occur.
The main treatments are:
Read more about how Paget's disease of bone is treated.
Paget's disease of bone can sometimes lead to further, potentially serious problems.
Read more about possible complications of Paget's disease of bone.
In addition to Paget's disease of bone, there are several other types of Paget's disease.
The general term "Paget's disease" is sometimes used to refer to Paget's disease of bone.